CARBAPENEM RESISTANCE DISSERTATION

Only meropenem is a substrate for the efflux pumps, due to the absence of a heterophilic side chain in the chemical structure of imipenem. February 03, ; Accepted: Data analysis The Fisher’s Exact Test were performed for all clinical data. In our study, only OXA type resistance is found in E. Siderophores in urinary tract infections are virulence factors frequently found in most pathogenic types of E. A new quorum-sensing inhibitor attenuates virulence and decreases antibiotic resistance in Pseudomonas aeruginosa.

Studies of isolates with decreased susceptibility to imipenem, and retained meropenem susceptibility, confirmed that down-regulation of oprD was the primary mechanism of resistance, although this was not found in all of the isolates. PCR products were analyzed by electrophoresis in a 1. Siderophores in urinary tract infections are virulence factors frequently found in most pathogenic types of E. The distribution of the virulence gene regions in E. Analysis of a carbapenem hydrolyzing class A b-lactamase from Enterobacter cloacae and of its LysR-type regulatory protein. Revista Latino-Americana de Enfermagem ; Also, the frequency of virulence gene regions in E.

The least common virulence gene region among strains is hly gene region responsible for hemolysis.

Virulence factors and drug resistance in Escherichia coli isolated from extraintestinal infections. A new quorum-sensing inhibitor attenuates virulence and decreases antibiotic resistance in Pseudomonas aeruginosa. Search for dissertations about: Studies of isolates with decreased susceptibility to imipenem, and retained meropenem susceptibility, confirmed that down-regulation of oprD was the primary mechanism of resistance, although this was not found in all of the isolates.

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The data of this study have been excerpted from the PhD thesis of the author. Indian Journal of Medical Microbiology ; Therefore, determining of beta-lactam group resistance, these mechanisms should be taken into consideration.

carbapenem resistance dissertation

Carbapenem gene regions of these isolates are given in Figure 1. Carbapenemase; Escherichia coli; multiplex polymerase chain reaction; virulence factor.

Search for dissertations about: “carbapenem resistant enterobacteriaceae”

Analysis of the carbapenemase gene regions Among E. Antibiotic resistance profiles and quorum sensing-dependent virulence factors in clinical isolates of Pseudomonas aeruginosa.

Naas T, Nordmann P. Journal of Hospital Infection ; Hemolysin hly is produced by various pathogenic types of E. Virulence factor gene profiles of E.

Carbapenem resistance in Pseudomonas aeruginosa

Extended-release ciprofloxacin as a novel treatment option. Current issues in the management of urinary tract infections: Multiplex PCR for detection of acquired carbapenemase genes. Similarly, virulence factors were highly found in carbapenem susceptible isolates, shows that other mechanisms may have an effect on the relation between carbapenem resistance and virulence. Existing mechanisms are mainly due to acquired carbapenemases or the combination of ESBL-production and reduced outer membrane permeability.

Malin Vading ; Karolinska Institutet. The decay acceleration factor DEF in humans, which is a glycoprotein found in hemopoietic, endothelial, intestinal and urinary dissertstion, is a receptor for afimbrial adhesin expressed with afa gene region. The Journal of Infectious Diseases ; ABSTRACT In this study, fifty Escherichia coli strains were analyzed by multiplex polymerase chain reaction for the genes expressed carbapenemase and virulence factors carbapeenm order to determine the presence of carbapenemase and nine virulence factors and investigate the association between these two characteristics.

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Clinical Microbiology and Infection ; Analysis of a carbapenem hydrolyzing class A b-lactamase from Enterobacter cloacae and of its LysR-type regulatory protein.

Escherichia Coli: Characteristics of Carbapenem Resistance and Virulence Factors

The Fisher’s Exact Test were performed for all clinical data. The most important virulence factors for urinary tract infections are fimbriae.

In this study, nine virulence gene regions pap, afa, fimA, sfa, hly, iroN, aer, cnf-1 and iutA for E. Carbapenem resistance in Pseudomonas aeruginosa.

carbapenem resistance dissertation

The mix for the detection of resisatnce groups afa-sfa-fimA, hly-iroN-aer-cnf1-iutA was at the same concentrations. Sfa gene region related with S fimbria is found in urinary tract infections as well as infections such as sepsis, meningitis like afa gene region.

February 03, ; Accepted: Show downloadable dissertations only. The genes encoding the MBLs are usually found on integrons, often embedded in functional transposons. The role of bacterial virulence and host factors in patients with Escherichia coli bacteremia who have acute cholangitis or upper urinary tract infection.

carbapenem resistance dissertation